Using LabVIEW 2012 SP1 f4; building on one computer and running on another via Runtime Engine. In addition to the RTE, I included VISA Configuration Support for MAX 5.2, NI-VISA Runtime 5.3, and NI-MAX 5.4. The first thing that came to my attention was that my instruments do not show up in MAX; serial ports aren't even listed at all. In my VI, I have a drop-down menu to select which COM port is for which instrument (the port number changes between building machine and running machine), and I can see the correct ports, but nothing can be written/read from these ports.
This is my first time building an application, also.